次世代創薬研究センター 所内プロジェクトセクション

研究内容

  1. 気象変動が自律神経機能と痛覚系に及ぼす影響:
    低圧低温環境シミュレータ,環境ストレスシミュレーション装置,小型気圧調節装置を利用し,気象要素(気圧変動,気温変化)が慢性痛モデル動物(ラット,マウス)と抑うつモデル動物,ならびに慢性痛・抑うつ患者(被験者)の疼痛レベルと自律神経機能に及ぼす影響に関する継続研究を行っている.

  2. 精神・神経疾患の機序解明と創薬標的分子の探索:
    精神・神経疾患の病因解明や新規治療戦略の開発に向けて,遺伝子改変マウスおよび疾患モデルマウスの行動解析を行い,以下のような研究成果を得た.

    (1) 精神疾患と意思決定:
     ヒトのIOWAギャンブル試験を反映した小動物用ギャンブル試験を開発した.また,病態モデル動物(統合失調症,躁病,覚せい剤精神病)は近視眼的意思決定を示すことがわかった.精神疾患の処方の導出に向けたトランスレーショナルリサーチとして,引き続き行っている.
    (2) アルツハイマー病モデルマウスの行動解析:
     アルツハイマー病モデルマウスの認知障害に対する新規治療薬候補の薬効解析を行った(共同/委託研究).

  3. 長期間ストレスの影響を解析する研究:
    小動物総合モニタリングシステム(CLAMS)を用いて,数週間以上の長期にわたって人工環境下で飼育したときの食餌量,飲水量,酸素消費量の変化を経時的に計測し,環境変化が動物の行動,代謝量に与える影響を解析している.また,小動物用コンパクトMRIシステムを用い,疾患モデル動物の病変部位の経過観察を行っている.

スタッフ (氏名をクリックすると、名古屋大学教員データベースの情報が表示されます)

助教 みぞぐち ひろゆき
溝口博之
助教 かのう やすひこ
加納安彦

業績

平成25年度

原著論文
  1. Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T,Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Rueani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K: Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia 61(5):679-693, 2013.
  2. Ohmichi M, Ohmichi Y, Ohnishi H, Yoshimoto T, Morimoto A, Li Y, Sakurai H, Nanano T, Sato J: Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization. Molecular Pain, in press, 2014.
  3. Mizoguchi H, Yamada K: Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures. Clinical Psychopharmacology and Neuroscience 11(2): 45–52, 2013.
著書・総説
  1. 佐藤純: 気象病と対策. 臨床整形外科 48(5): 458−461, 2013.

平成24年度

原著論文
  1. Takuma K, Mizoguchi H, Funatsu Y, Hoshina Y, Himeno Y, Fukuzaki E, Kitahara Y, Arai S, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K: Combination of chronic stress and ovariectomy causes conditioned fear memory deficites and hippocampal cholinergic neuronal loss in mice. Neuroscience 207: 261-73, 2012.
  2. Nakamoto K, Kawasaki S, Kobori T, Fujita-Hamabe W, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S: Involvement of matrix metalloproteinases-9 in the development of morphine tolerance. European Journal of Pharmacology 683(1-3): 86-92, 2012.
  3. Takuma K, Mizoguchi H, Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T, Yamada K: Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice. Journal of Pharmacological Sciences 120: 89-97, 2012.
  4. Arai YCP, Morimoto A, Sakurai H, Ohmichi Y, Aono S, Nishihara M, Sato J, Ushida T, Inoue S, Kurisuno M, Kobayashi Y: The effect of celiac plexus block on heart rate variability. Journal of Anesthesia 27(1): 62-65, 2013.
  5. Arai YCP, Nishihara M, Kobayashi K, Kanazawa T, Hayashi N, Tohyama Y, Nishida K, Arakawa M, Suzuki C, Kinoshita A, Kondo M, Matsubara S, Yokoe N, Hayashi R, Ohta A, Sato J, Ushida T: Neurolytic celiac plexus block reduces occurrence and duration of terminal delirium in patients with pancreatic cancer. Journal of Anesthesia 27(1): 88-92, 2013.
  6. Morimoto A, Winaga H, Sakurai H, Ohmichi M, Yoshimoto T, Ohmichi Y, Matsui T, Ushida T, Okada T, Sato J: Treadmill running and static stretching improve long-lasting hyperalgesia, joint limitation, and muscle atrophy induced by cast immobilization in rats. Nuroscience Letters 534: 295-300, 2013.
著書・総説
  1. 佐藤 純:天気と病気.未来へつなぐたからもの 持続可能な社会を考える118-129, 2012.

平成23年度

原著論文
  1. Watanabe C, Seino Y, Miyahara H, Yamamoto M, Fukami A, Ozaki N, Takagishi Y, Sato J, Fukuwatari T, Shibata K, Oiso Y, Murata Y , Hayashi Y: Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides. Diabetes 61: 74−84, 2012.
  2. Mizoguchi H, Yamada K, Nabeshima T: Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy. Biochemistry Research International 2011:681385, 2011.
  3. Naruse K, Sato J, Funakubo M, Hata M, Nakamura N, Kobayashi Y, Kamiya H, Shibata T, Kondo M, Himeno T, Matsubara T, Oiso Y, Nakamura J: Transplantation of bone marrow-derived mononuclear cells improves mechanical hyperalgesia, cold allodynia and nerve function in diabetic neuropathy, PLosOne 6(11): e27485, 2011.
  4. Furukawa-Hibi Y, Alkam T, Nitta A, Matsuyama A, Mizoguchi H, Suzuki K, Moussaoui S, Yu QS, Greig NH, Nagai T, Yamada K: Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice. Behavioural Brain Research 225(1):222-9, 2011.
  5. Sato J, Itano Y, Funakubo M, Mizoguchi H, Itoh M, Mori R: Low barometric pressure aggravates neuropathic pain in guinea pigs. Neuroscience Letters 503(2): 152-156, 2011.
  6. Mizuno T, Doi Y, Mizoguchi H, Jin S, Noda M, Sonobe Y, Takeuchi H, Suzumura A: Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-β neurotoxicity. The American Journal of Pathology 179(4): 2016-27, 2011.
  7. Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K: Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. The Journal of Neuroscience 31(36): 12963-12971, 2011.
  8. Shichi K, Fujita-Hamabe W, Harada S, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S: Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. Journal of Pharmacology and Experimental Therapeutics 338(2): 701-10, 2011.
  9. Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K, Yamada K: Nicotine ameliorates impairment of working memory in methamphetamine-treated rats. Behavioural Brain Research 220(1): 159-163, 2011.
  10. Takeuchi H, Mizoguchi H, Doi Y, Jin S, Noda M, Liang J, Li H, Zhou Y, Mori R, Yasuoka S, Li E, Parajuli B, Kawanokuchi J, Sonobe Y, Sato J, Yamanaka K, Sobue G, Mizuno T, Suzumura A: Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. PLoS One 6(6): e21108, 2011.
  11. Funakubo M, Sato J, Obata K, Mizumura K: The rate and magnitude of atmospheric pressure change that aggravate pain-related behavior of nerve injured rats. International Journal of Biometeorology 55(3): 319-326, 2011.
  12. Matsubara T, Arai YCP, Shiro Y, Shimo K, Nishihara M, Sato J, Ushida T: Comparative effects of acupressure at local and distal acupuncture points on pain conditions and autonomic function in females with chronic neck pain. Evidence-Based Complementary and Alternative Medicine, 2011 Article ID 543291, 2011.
著書・総説
  1. 松原貴子,城由起子,西原真理,栗巣野誠,新井健一,下和弘,佐藤純,牛田享宏経皮吸収型NSAID塗布剤ロキソニンゲルの鎮痛および疼痛関連症状緩和作用-いわゆる肩凝りに対するロキソプロフェンナトリウム水和物含有塗布剤(ロキソニンゲル1%)の有効性-.ペインクリニック 32(5): 715-719, 2011.
  2. 佐藤純:ストレスと痛み.ペインクリニック 32(12), 2011.

平成22年度

原著論文
  1. Mizoguchi H, Fukaya K, Mori R, Itoh M, Funakubo M, Sato J: Lowering barometric pressure aggravates depression-like behavior in rats. Behavioural Brain Research 218(1): 190-193, 2011.
  2. Mizoguchi H, Yamada K: Pharmacologic treatment with GABAB receptor agonist of methamphetamine-induced cognitive impairment in mice. Current Neuropharmacology 9(1): 109-112, 2011.
  3. Sakurai H, Sato J, Yoshimoto T, Ohmichi Y, Morimoto A, Arai YCP, Ushida T: Examination of subjective sensations and vasomotor reaction to environmental temperature changes in chronic pain patients with impaired cold sensation. Pain Research, 26(1): 11-18, 2011.
  4. Messlinger K, Funakubo M, Sato J, Mizumura K :Increases in neuronal activity in rat spinal trigeminal nucleus following changes in barometric pressure-relevance for weather-associated headache. Headache 50(9): 1449-1463, 2010.
  5. Matsubara T, Arai YC, Shimo K, Sato J, Osuga T, Nishihra M, Ushida T: Effects of cognitive-behavioral therapy on pain intensity and level of physical activity in Japanese patients with chronic pain-a preliminary quasi-experimental study. Journal of Physical Therapy 1(2): 49-57, 2010.
  6. Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T, Yamada K: Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4. Journal of Neurochemistry 114(6): 1840-1851, 2010.
  7. Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, Nabeshima T:Oral supplementation with Leu-lle, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated. Behavioural Brain Research 210(2): 184-190, 2010.
  8. Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G: Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy. The Journal of Neuroscience 30(16): 5702-5712, 2010.
  9. Mizoguchi H, Ibi D, Takuma K, Toth E, Sato Jun, Itohara S, Nabeshima T, Yamada K: Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice. The Open Behavioral Science Journal 4: 19-25, 2010.
  10. Arai PYC, Kandatsu N, Ito H, Sato J, Ushida T, Suetomi K, Nishihara M, Matsubara T, Komatsu T: Behavior of children emerging from general anesthesia correlates with their heart rate variability. Journal of Anesthesia 24(2): 317-318, 2010.
著書・総説
  1. 佐藤純:天気変化と痛み.Anesthesia Network. 15(1): 32-34, 2011.
  2. 佐藤純,溝口博之,深谷佳乃子:天候変化と気分障害.日本生気象学会雑誌 48(1): 3-7, 2011.
  3. 佐藤純:リウマチ・関節炎.からだと温度の辞典.199-201, 2010.

更新日:2015年4月6日